Nūhou - Hoʻohana ʻia o ka Zinc Oxide maʻamau i ka Anti-diarrhea o nā puaʻa

ʻO wau.

ʻOkika zinc, i ʻike nui ʻia ʻo zinc white, he amphoteric iaʻokikene zincʻaʻole ia he mea hoʻoheheʻe i ka wai akā hoʻoheheʻe ʻia i ka waikawa a me ka alkali ikaika. ʻO kona ʻano kemika ʻo ZnO, ʻo ke kaumaha molekala he 81.37, ʻo ka helu CAS he 1314-13-2, ʻo ke kiko heheʻe he 1975 ℃ (decomposition), ʻo ke kiko paila he 2360 ℃, a ʻaʻole ia he mea hoʻoheheʻe i ka wai. Hoʻohana nui ʻia ia ma mua o 20 mau kahua e like me nā plastics, nā huahana silicate, ka rubber synthetic, nā lubricants, nā pena a me nā uhi, nā poni, nā mea hoʻopili, ka meaʻai, nā pila, nā mea pale ahi,a pēlā aku.

Kiʻi 1ʻOkika zinchāpana

III. Nā pilikia o ka maʻi diarrhea i nā puaʻa i hoʻopau ʻia a me ka waiwai lapaʻau oʻokikene zinc

He mea hoʻoluhi nui ka hoʻopau ʻana i ka waiū umauma i ke ola o kahi puaʻa. ʻO nā pilikia e like me ka nāwaliwali o ka hana pale ʻōpū, ka lawa ʻole o ka hoʻokuʻu ʻana o nā enzyme digestive, a me ke kaulike ʻole o nā flora e alakaʻi pinepine ai i ka maʻi diarrhea ma hope o ka hoʻopau ʻana i ka waiū umauma (PWD), kahi e hoʻoweliweli nui ai i ka hana ulu a me nā pono hānau o nā puaʻa. Mai ka wā maʻamauʻokikene zincua ʻike ʻia he hopena koʻikoʻi anti-diarrhea i nā makahiki 1980, ua lilo ia i "kūlana gula" no ka ʻoihana holoholona honua e hana me PWD. Ua hōʻike ʻia nā haʻawina e hoʻohui ana i 2500-3000 mg/kgʻokikene zinchiki ke hōʻemi i ka nui o ka maʻi diarrhea ma 40%-60%, ʻoiai e hoʻonui ana i ka piʻi ʻana o ke kaumaha i kēlā me kēia lā ma 10%-15%. ʻO kona waiwai nui ka hoʻopaʻa koke ʻana i ke kaiapuni ʻōpū ma o nā ʻano hana he nui, e hāʻawi ana i ka palekana hoʻololi koʻikoʻi no nā puaʻa.

Nā pilikia o ka maʻi diarrhea i nā puaʻa i hoʻopau ʻia a me ka waiwai lapaʻau o ka zinc oxide

ʻEhā.Ke ʻano hana oʻokikene zince kū'ē i ka maʻi pākī

1)Ke hoʻoikaika nei i ka pale kino o ka ʻōpū

ʻOkika zincHoʻoulu i ka hoʻolaha ʻana o nā pūnaewele epithelial intestinal, hoʻonui nui i ka lakio o ke kiʻekiʻe o ka villus intestinal i ka hohonu o ka crypt, hoʻomaikaʻi i ka ʻili no ka omo ʻana o nā meaʻai, a hoʻonui pū i ka hōʻike ʻana o nā protein tight junction (Occludin, ZO-1), hoʻemi i ka permeability mucosal intestinal, a ālai i ka hoʻouka kaua ʻana o nā pathogens. Mālama ia i ka hana pale mucosal intestinal, hoʻomaikaʻi i ka hiki ke antibacterial o nā puaʻa, a hoʻemi i ka maʻi diarrhea.

Kiʻi 2Nā hopena o nā lāʻau like ʻole oʻokikene zincma ke ʻano o ka ʻōpū o nā puaʻa

Kiʻi 3 Nā hopena o nā ʻano like ʻole o ka zinc oxide ma nā protein intestinal tight junction i loko o nā puaʻa

Kiʻi 3Nā hopena o nā lāʻau like ʻole oʻokikene zincma nā protein intestinal tight junction i loko o nā puaʻa

2)Ke hoʻoponopono nei i ke kaulike microbial intestinal

ʻOkika zinchoʻopuka i nā radical free hydrogen peroxide i loko o ka ʻōpū, he mea nui ia i ka hana antibacterial oʻokikene zinc. Kiʻekiʻe-lāʻauʻokikene zinchoʻopale pololei i ka hoʻolaha ʻana o nā bacteria pathogenic e like me Escherichia coli lāua ʻo Salmonella ma o ka hoʻokuʻu ʻana i nā reactive oxygen species (ROS), ʻoiai e paipai ana i ka kolone ʻana o nā bacteria maikaʻi e like me Lactobacillus.

Kiʻi 4Nā hopena o ka meaʻaiʻokikene zincma nā microorganism cecal i loko o nā puaʻa

3) Hoʻoulu ka zinc kiʻekiʻe i ka ulu ʻana o nā puaʻa

ʻO ke kaumaha o ka weaning e hōʻemi ai i ka 30% o ka digestibility o ka hānai, a ʻoi aku ka emi ʻana o ka ʻai ʻana o nā meaola i loko o nā puaʻa i hoʻopau ʻia i ka waiū i ka wā e maʻi ana lākou. Ua hōʻike ʻia nā haʻawinakēlāka hoʻohui ʻana i nā dosis kiʻekiʻe oʻokikene zinchiki i ka ʻai ʻana ke hoʻonui i ka pae zinc i loko o ke koko, hoʻoponopono hou i ka hoʻokuʻu ʻana o nā peptides ʻōpū o ka lolo a me nā hormones pōloli, a mehoʻoulu i nā puaʻa e ʻai. I ka manawa like, ka hoʻonui ʻia o ka nui o ka zinc i loko o ke kokohikihoʻoikaika maikaʻi i ka synthesis a me ka hoʻoulu ʻana o nā enzyme digestive, hoʻomaikaʻi i ka digestibility o nā meaʻai, a mee hoʻonui i ka kaumaha o nā puaʻa i kēlā me kēia lā.

Kiʻi 5Nā hopena o ka zinc oxide i ka ulu ʻana o nā puaʻa i hoʻemi ʻia

IV. Hoʻolālā Noi ʻEpekema a me nā Mālama

1. Ka nui pololei a me ke kaʻina hana hoʻohana

ʻOiai ua ʻōlelo ʻia he nui ka zinc (1600-2500 mg/kg)ʻokikene zinc) hiki ke hoʻohana wale ʻia ka hānai i loko o ka"ʻelua pule mua ma hope o ka hānai ʻana", hoʻolōʻihi ka nui o nā mahi puaʻa i ka hoʻohana ʻana i ka hānai zinc kiʻekiʻe no 2-8 mau pule. I kēia manawa, e ʻike kekahi mau mahi puaʻa"nā hopena ʻaoʻao zinc kiʻekiʻe", i ʻike pinepine ʻia he lauoho mānoanoa a lōʻihi a me ka ʻili palalulu.

2. Kohoʻokikene zincme ke kūpaʻa kiʻekiʻe e hoʻomaikaʻi i ka hopena o ka huahana

ʻO ka bioavailability oʻokikene zincʻoi aku ka nui o ka mea i hana ʻia e ke kaʻina hana pulu ma mua oʻokikene zinci hana ʻia e ke kaʻina hana pololei. No laila, i ke koho ʻanaʻokikene zincnā huahana, pono e noʻonoʻo ʻia hoʻi ke kaʻina hana.

5. Nā ʻAno Hana a me nā Manaʻo ʻenehana ʻē aʻe

ʻOiai ua kaupalena ka EU i ka nui o ka zinc i hoʻohui ʻia i 150 mg/kg, hōʻike ka hana kūloko e kū mau ana ka hoʻololi piha ʻana i ka zinc kiʻekiʻe i nā pilikia loea. ʻO nā koho ʻē aʻe o kēia manawa e like me nanoʻokikene zinc(300 mg/kg) a me ka zinc chloride kumu (1200 mg/kg) hiki ke hōʻemi i ka nui o ka lāʻau, akā kiʻekiʻe ke kumukūʻai o lākou, ʻaʻole lawa ka paʻa o ke kaʻina hana, a pono e hōʻoia ʻia ka palekana lōʻihi. No laila,maʻamauʻokikene zincʻo ia nō ke koho maikaʻi loa no nā mahiʻai liʻiliʻi a me waena e kaulike i ke kumukūʻai a me ka hopena.